伍哲緯（Che Wei Wu） 助理教授

分機8496  

email:

tetsuigo@mail.ypu.edu.tw

學歷:

日本國立筑波大學生命環境科學博士

專長領域：

骨科學

心血管研究

脂肪幹細胞

組織工程

再生醫學

細胞內訊息傳遞

外泌體

粒線體

A.期刊論文(皆為SCI期刊)

1. Chih-Yun Lee; Swathi Nedunchezian; Sung-Yen Lin; Yu-Feng Su; Che-Wei Wu; Shun-Cheng Wu; Chung-Hwan Chen; Chih-Kuang Wang. Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel. Journal of Biological Engineering. 2023 (74). IF: 6.248
2. Han Lee; Jiunn-Der Liao; Tak-Wah Wong; Che-Wei Wu; Bo-Yao Huang; Shun-Cheng Wu; Pei-Lin Shao; Yu-Han Wei; Ming-Hsien Cheng. Detection of micro-plasma-induced exosomes secretion in a fibroblast-melanoma co-culture model. Analytica Chimica Acta 2023(15),  341910. IF:6.911
3. Ling-Hua Chang; Shun-Cheng Wu; Chung-Hwan Chen; Jhen-Wei Chen; Wan-Chun Huang; Che-Wei Wu; Yi-Shan Lin; Yu-Ju Chen; Je-Ken Chang; Mei-Ling Ho. Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression. Int. J. Mol. Sci. 2023, 24(17), 13414. IF:5.6
4. Mei-Ling Ho; Chin-Jung Hsu; Che-Wei Wu; Ling-Hua Chang; Jhen-Wei Chen; Chung-Hwan Chen; Kui-Chou Huang; Je-Ken Chang; Shun-Cheng Wu; Pei-Lin Shao. Enhancement of Osteoblast Function through Extracellular Vesicles Derived from Adipose-Derived Stem Cells. Biomedicines 2022, 10(7), 1752. IF: 4.757.
5. Swathi Nedunchezian; Che-Wei Wu; Shung-Cheng Wu; Chung-Hwan Chen; Je-Ken Chang; Chih-Kuang Wang. Characteristic and Chondrogenic Differentiation Analysis of Hybrid Hydrogels Comprised of Hyaluronic Acid Methacryloyl (HAMA), Gelatin Methacryloyl (GelMA), and the Acrylate-Functionalized Nano-Silica Crosslinker. Polymers 2022, 14(10), 2003. IF: 4.967
6. Shun-Cheng Wu, Chih-Hsiang Chang, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Yi-Shan Lin, Je-Ken Chang, Mei-Ling Ho. Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment. Biomedicines 2021, 9(5), 559. IF: 5.61
7. Swathi Nedunchezian, Parikshit Banerjee, Chih-Yun Lee, Su-Shin Lee, Che-Wei Lin, Che-Wei Wu, Shun-Cheng Wu, Je-Ken Chang, Chih Kuang Wang. Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis. Mater. Sci. Eng. C. 2021 May;124:112072. IF:5.880
8. Che Wei Wu, Yoshihiro Nakamoto, Takumaru Hisatome, Shigeki Yoshida, Hitoshi Miyazaki. Resveratrol and its dimers ε-viniferin and δ-viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy. Kaohsiung J Med Sci.2020 (7):535-542. IF: 1.737
9. Ming-Wei Hung, Che-Wei Wu, Daichi Kokubu, Shigeki Yoshida, Hitoshi Miyazaki. ε-Viniferin is More Effective than Resveratrol in Promoting Favorable Adipocyte Differentiation with Enhanced Adiponectin Expression and Decreased Lipid Accumulation. Food Sci Technol Res.  2019 (25): 817-826. IF:0.448

B.研討會論文

1. 邵佩琳, 伍哲緯, 盧政昌, 張玲華, 陳振偉, 陳崇桓, 張瑞根, 何美泠, 陳禾桂, 吳順成 Adipose-derived stem cells co-culture with chondrocytes secrete extracellular vesicles maintain chondrogenic phenotype of monolayer-expanded chondrocytes. 2024 年台灣再生醫學學會學術研討會 March 2, 2024
2. 陳禾桂, 邵佩琳, 伍哲緯,盧政昌, 張玲華, 陳振偉, 陳崇桓, 張瑞根, 何美泠, 吳順成 Adipose-derived stem cells co-culture with chondrocytes secrete extracellular vesicles maintain chondrogenic phenotype of osteoarthritic chondrocytes 2024 年台灣再生醫學學會學術研討會 March 2, 2024
3. 邵佩琳, 伍哲緯, 黃耀輝, 張玲華, 陳振偉, 鄒亞璇, 何美泠, 吳順成 Adipose-derived stem cells mitochondrial transfer recovers mitochondrial and cartilage functions of senescent chondrocytes. 2024 年台灣再生醫學學會學術研討會 March 2, 2024
4. 伍哲緯, 林怡文, 黃婉君, 王彥雄, 李天慶, 傅尹志 Rabbit organoid kidney transplantation by using scCO2 decellularized method and development of in vivo 3D bio-scaffold  2024年台灣再生醫學學會學術研討會 March 2, 2024
5. 伍哲緯, 林怡文, 黃婉君, 王彥雄, 李天慶, 傅尹志 scCO2 decellularized rabbit kidney bio-scaffold promoted Adipose-derived stem cell differentiation 2024年台灣再生醫學學會學術研討會 March 2, 2024
6. 鄒亞璇, 莊淑君, 伍哲緯, 陳崇桓, 何美泠, 張瑞根 Activation of G Protein-coupled Estrogen Receptor-1 Reduces Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating the Cytoskeleton. 活化GPER-1 調控細胞骨架抑制骨髓間質幹細胞的成骨分化 2023 年台灣再生醫學學會學術研討會 March 25, 2023
7. 吳順成, 張玲華, 陳振偉, 伍哲緯, 陳崇桓, 張瑞根, 何美泠 Extracellular Vesicles Released from Human Adipose-derived Stem Cells Reduce Senescence and Dedifferentiation of Chondrocyte 脂肪幹細胞分泌之細胞外囊泡可減少關節軟骨細胞之老化及去分化 2023 年台灣再生醫學學會學術研討會 March 25, 2023
8. 伍哲緯, 黃耀輝 ,邵佩琳, 張玲華, 陳振偉, 何美泠, 吳順成 Mitochondrial Transfer Suppresses Senescence and Mitochondrial Oxidative Stress in Chondrocytes 粒線體移植抑制軟骨細胞的老化與粒線體氧化壓力 2023 年台灣再生醫學學會學術研討會 March 25, 2023
9. 伍哲緯, 何美泠, 陳振偉, 陳崇桓, 吳順成, 邵佩琳 The Study of Extracellular Vesicles Isolated from Adipose Derived Stem Cells on Functions of Osteoblasts During Bone Tissue Engineering 探討脂肪幹細胞分泌之細胞外囊泡在骨組織工程中對於成骨細胞功能之影響 2023 年台灣再生醫學學會學術研討會 March 25, 2023
10. Shun-Cheng Wu, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho*; Enhancement of senescent chondrocyte function by extracellular vesicles released from human adipose-derived stem cells; Orthopaedic Research Society 2023 Annual Meeting; USA, Hilton Anatole, Dallas, Texas, February 10-14, 2023.
11. Che-Wei Wu, Yao-Hui Huang, Pei-Ling Shao, Ling-Hua Chang, Jhen-Wei Chen, Mei-Ling Ho, Shun-Cheng Wu*; Mitochondrial transfer suppresses senescence induced mitochondrial dysfunction and oxidative stress in chondrocytes; Orthopaedic Research Society 2023 Annual Meeting; USA, Hilton Anatole, Dallas, Texas, February 10-14, 2023.
12. Che-Wei Wu, Mei-Ling Ho, Jhen-Wei Chen, Shun-Cheng Wu, Pei-Lin Shao Enhancement of osteogenesis of osteoblasts in vitro by extracellular vesicles derived from adipose derived stem cells 2023 亞太胞外體學會大會; 國家生技研究園區(臺北市南港區研究院路一段130巷99號C棟); March 31-April 2, 2023.
13. Shun-Cheng Wu; Ling-hua Chang; Che-Wei Wu; Chung-Hwan Chen; Je-Ken Chang; Mei-Ling Ho; Extracellular Vesicles Released From Human Adipose-derived Stem Cells Reduce Senescence And Dedifferentiation Of Articular Chondrocyte; Orthopaedic Research Society 2022 Annual Meeting; USA, Florida, February 4-8, 2022.
14. 伍哲緯, 何美泠, 張瑞根, 陳崇桓, 黃揆洲, 許晉榮,吳順成*,邵佩琳* Characterization of Adipose Derived Stem Cells-Derived Extracellular Vesicles and Its Effects on Osteoblastic Functions 脂肪幹細胞分泌之細胞外囊泡之鑑定及其對於成骨細胞之功能 Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會110 年度第80次聯合學術研討會、December 30-31, 2021
15. Shun-Cheng Wu, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho*  Extracellular vesicles released from human adipose-derived stem cells enhance articular chondrocyte function. Orthopaedic Research Society 2021 Annual Meeting; All access, February 12-16, 2021.
16. 吳順成, 陳振偉, 伍哲緯, 張玲華, 陳崇桓, 張瑞根*, 何美泠* Extracellular vesicles released from human adipose-derived stem cells enhance articular chondrocyte function. 人類脂肪幹細胞釋放的細胞外囊泡可增強關節軟骨細胞功能 Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科醫學會109年度第78次聯合學術研討會 October 24-25, 2020.
17. Shun-Cheng Wu, Jhen-Wei Chen, Che-Wei Wu, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho Adipose-derived stem cells enhance chondrogenesis and cartilaginous matrix synthesis of articular chondrocytes is mediated by extracellular vesicles. Orthopaedic Research Society 2020 Annual Meeting; USA, Phoenix, February 8-11, 2020.
18. Shun-Cheng Wu, Jhen-Wei Chen, Che-Wei Wu, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho. Adipose-derived stem cells enhance chondrogenesis and cartilaginous matrix synthesis of articular chondrocytes is mediated by extracellular vesicles. The International Society for Extracellular Vesicles 2019; Kyoto, Japan, April 24-28, 2019.